GENACOL® - A NEW DISCOVERY

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Collagen Products Are Not All the Same

Let me begin by saying that I do not own a single share of the Genacol® Company, nor have I ever been paid a cent to recommend the Genacol® product any more than I have been for the other products that I recommended in this book. However, I have examined the vast majority of all the collagen products in the market and have found that Genacol® is by far the best.

Not all collagen products are the same, and not all provide a medicinally effective collagen. Most collagens are so poorly absorbed that they are a waste of money. Of the very few collagen products that remain, most have a very low absorption, rate, something in the neighbourhood of twenty percent.

There are only two collagen products that are of help in weight loss, injury repair, and skin enhancement. One is a Type II liquid collagen and the other is Genacol®, a collagen matrix delivered in capsule form. Genacol® is the best of the products because it is, first of all, a collagen matrix. It stimulates production of all kinds of collagen rather than furnishing only one of the fourteen. Genacol® is produced from pure collagen through a difficult formulation process carried out in Canada as a result of a partnership between DirectLab and a French formulator. The end product is Genacol®, which has been demonstrated to have the highest bioavailability of any of the collagen products, including the liquid.

A little known fact is that any type of collagen, especially Type II, begins to degrade the moment it is exposed to liquid. Thus, liquid preparations made with this kind of collagen start degrading immediately. To stop this, fillers, preservatives, and other ingredients are added to slow the process. This additional processing causes a negative bioconversion, which limits the product’s effectiveness.

In a very significant three-month study that compared Genacol® with a liquid and a market collagen, Dr. Stephen Ho, a well-known trauma physician, evaluated the results using five groups of test subjects. Each group consisted of 30 subjects, all similar in size, weight, health condition, age, and gender.

The first group was given the Genacol® product to be taken over a 90-day period; the second group took the liquid collagen; the third group received a common drug store market collagen supplement; and the fourth group was given a placebo composed of neutral ingredients; while the fifth group (the control group) was given nothing at all.

A physical history was taken before and after the 90-day study to compare the groups. The Genacol® Group scored the best, followed by the liquid collagen, the market collagen, the placebo, and then the control group. The study was independent, and Dr. Ho was not paid by any commercial entity for conducting it. Table I summarizes the results.

TABLE 1 Comparison Study Collagen Matrix and Type II Collagen, Findings Summary
Test Groups	Group I Genacol®	Group II Liquid Collagen	Group III Market Grade Collagen	Group IV Placebo	Group V Control Group
Reduction in Aches & Pains	Considerable	Favourable	Some	Some	None
Noticeable Change in Skin	Considerable	Favourable	Very Little	None	None
Noticeable Feelings of Youth & Vigour	Considerable	Favourable	Very Little	Small	None

The Genacol® group recorded considerable improvements in the reduction of weight and body fat together with a considerable reduction in aches and pains. This group also recorded noticeable increases in their feelings of youth and vigour. The liquid collagen group, using a collagen Type II in a liquid form, demonstrated improvements but nearly 30% less than the Genacol® group. Group III, which was administered an over-the-counter market collagen, showed only nominal improvement. The placebo group, Group IV received only a non- bioactive capsule. There were minor improvements recorded, most of which can be accounted for psychologically because they expected results. This group was unaware that it was not being given a collagen at all.

The Control group, Group V, was given neither collagen Type II nor a placebo. In composition, age, gender, and health, they were similar to Groups I through IV. Histories were taken at the beginning of the study and at the end. Other than a minor weight and body fat increase, no other changes were observed.

Dr. Ho’s conclusion was that the Genacol® brand collagen matrix in its pure, dry- state form was far superior to that of the liquid or the market collagens. He also concluded that Genacol®, taken on a regular basis, resulted in a more youthful appearance and feeling. Pains were reduced along with a significant decrease in body weight and body fat. He also reported that the group taking Genacol® reported a more restful and longer sleep period and more energy during the activity hours. In a national network television broadcast on aging, Dr. Sal Martingano, one of the nation’s experts on collagen Type II, explained why the Genacol® product fared so much better in the comparison study.

Dr. Jean-Yves Leroux, a Canadian immunologist and biochemist who is heavily involved in the Genacol® studies, concurred. Genacol’s Formulator, Canadian Guy Michaud, stressed in a personal conversation with me, that the decision was made early to develop a processing system that would enable the Genacol® Collagen Matrix to be nearly 100% bio-Myexperience and research has found that the delicate process ofutilizing collagen is destroyed ifthe collagen, even a collagen matrixis manufactured by the traditional heat extraction process.

Products that have collagen in a solution mixture begin the process ofoxidation and loss ofpotencylong before you use it, which allows onlya fraction ofthe collagen content to be absorbed. The ideal state ofbodycollagen is without water or other solvents. Pure collagen is virtuallya pre-digested molecule meaning that the bodycan absorb directlythrough the stomach lining without the diminishing effects ofacid breakdown.(33)

We consider using a liquid base because the mediumwould have cost far less than the process that we nowuse. The problemis degradation ofthe collagen. It starts deteriorating almost immediately. To keep that fromhappening, we would have to add preservatives and other chemicals as liquid collagen makers have. Done. This only helps marginally and creates other problems for the collagen available to the body. (34)

As a result of a trade secret non-homogenized cold press system, Genacol® can be absorbed directly as it enters the stomach, avoiding the diminishing effects of acid breakdown from further digestion. Dr. Patrick Price, a Houston health professional, conducted another sizable independent study of Genacol® which used three groups of patients that were essentially identical in makeup. Dr. Price found that Genacol® produced highly observable improvement in energy, arthritic and injury pain relief, and skin texture. A placebo group had only minor improvements, and the control group, like the one in Dr. Ho’s study, remained the same.

The findings of the recent research studies of Drs. Stephen Ho and Patrick Price produced results in keeping with many other collagen studies that have been conducted at research facilities worldwide.

The conclusion is this: the collagen matrix and collagen Type II work. The matrix is better. Independent research has shown Genacol® to be the most usable and easiest to assimilate of all the collagen products available in the market place. I asked the Genacol® Company to provide an address where their product could be ordered. In reply, they also permitted a discount coupon to be included at the back of the book that may be used to order the product. As I said earlier, I do not own stock in the company, but I am convinced of the product’s usefulness in helping people look and feel younger at any age. Losing the additional weight and body fat are not bad side effects either.

SUMMARY

There are 14 collagens that make up most of the body’s skin, tendons, bone, cartilage, and other connective tissues. Although naturally produced by the body, collagen production declines after 25. By age 55, over 15% of the body’s production capacity is gone. After age 70, the loss is over 30% and climbing.

Much of the body’s repair work occurs at night. Under the right conditions, increased weight loss can occur during this period. As the body’s collagen production declines so does the body’s amount of sleep time.

Degenerative collage diseases associated with aging affect the entire body. Collagen diseases include arthritis, fibromyalgia, bursitis, tendonitis, and other associated conditions. Wrinkling, age spots, and joint pain are symptoms of degenerating collagen.

Recently, new collagen products have emerged in the market that helps with collagen disease. These tend to be collagen Type II, collagen matrix, and the collagen derivative products such as glucosamine-chondroitin. Of the three, the collagen matrix has tested superior to the others.

The recommended form of Matrix is Genacol®, which foregoes the pasteurization and immersion in liquid process. This keeps the product far more bioactive that other products that have been clinically tested.

For additional reading material concerning Collagen and Genacol, please click this link to view "Rx for Youth" by Warren Chaney, PhD.

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1 Miller-Keane Medical Dictionary, 2002.

2 A. Berton, V. Rigot, E. Huet, M. Decarme, Y. Eeckhout, L. Patthy, G. Godeau, W. Hornebeck, G. Bellon, and H. Emonard. Involvement of Fibronectin Type II Repeats in the Efficient Inhibition of Gelatinases A and B by Long-chain Unsaturated Fatty Acids, Journal Of Biological Chemistry, June 2001.

3 Alex Suh, DC, during a personal interview conducted during April 2003.

4 Shelton, Gene; Collagen Type II and Arthritis, Health Remedies Notebook, 2002.

5 National Cardiovascular Disease Statistics, Office of the Surgeon General, Washington, D.C. 2003.

6 Ibid.

7 Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis, a Harvard School of Medicine Study published in the Journal of Science, Boston, Massachusetts, September 1993.

8 National Cardiovascular Disease Statistics, Office of the Surgeon General, Washington, D.C” 2003.

9 Ibid.

10 Cochran, Charles; Lubricate Your Joints, Canadian Journal of Health and Nutrition, March 2001.

11 Christopher M. Overall, Angela E. King, Douglas K. Sam, Aldrich D. Ong, Tim T.Y. Lau, U. Margaretha Wallon, Yves A. DeClerck, and Juliet Atherstone. The Hierarchical Role in Binding Timp-2 of the Unique Cationic Clusters of Hemopexin Modules Iii and Iv; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Colombia V6T 1Z3, Canada and the Division of Hematology-Oncology, Children’s Hospital Los Angeles and University of Southern California, Los Angeles, California, 1998.

12 Ibid.

13 Tuan, T.-L., Song, A.K., Chang, S., Younai, S., and Nimni, M.E. In vitro fibroplasia: Matrix contraction, cell growth, and collagen production of fibroblasts cultured in fibrin gels. Experimental Cell Research, 223:127-134; 1996.

14 O. Steinbrocker, C.H. Traeger, R.C. Batterman, J.Am. Med. Assoc. 155, 1949 and as referenced and detailed by Dr. Sal Martingano in his Collagen Audio Series, Florida, 2001.

15 Li S, Fan Y-S, Chow LH, Van Den Diepstraten C, van der Veer E, Sims S, Pickering JG (2001) Innate diversity of adult human arterial smooth muscle cells: cloning of distinct subtypes from the internal thoracic artery. Circulation Research, 89:517-525.

16 Ibid.

17 Michael W. Smith, Understanding Arthritis, Treatment and Detection, June 2002.

18 Anu Muona: Type XV Collagen. Complete structures of the human COL15A1 and mouse Col15a1 genes, location of type XV collagen protein in mature and developing mouse tissues, and generation of mice expressing truncated type XV collagen. Acta Universitatits Ouluensis D 662, 2001.

19 Dr. Sal Martingano, one of the nation’s acknowledged collagen experts and researchers, speaking in a taped national radio broadcast appearance, Reasons for Aging, 20002.

20 Di Giovanna, Augustine G. Human Aging: Biological Perspectives, New York: McGraw-Hill, 1994.

21 Ibid.

22 Leroux, Jean-Yves, Ph.D., a well know Canadian immunologist specializing in collagen research, speaking during a nationally broadcast television special, The Loss of Youth, 2003.

23 Kari Kivirikko, M.D., Ph.D. and Taina Pihlajaniemi, M.D., Ph.D. Molecular biology of collagens and enzymes of collagen biosynthesis. Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology University of Oulu, Finland, 2001.

24 Kari Kivirikko, M.D., Ph.D. and Taina Pihlajaniemi, M.D., Ph.D. Molecular biology of collagens and enzymes of collagen biosynthesis. Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology University of Oulu, Finland, 2001.

25 Collagen Studies, Brown University – Department of Orthopedics, 1997.

26 Bjorn Steffensen Dagger, Heather F. Bigg, and Christopher M. Overall; The Involvement of the Fibronectin Type II Modules of Human Gelatinase A in Cell Surface Localization and Activation; ABSTRACT from the Faculty of Dentistry and Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

27 Ho, Stephen, MD, A Catalistic Study of Collagen Interaction, Journal of Applied Research, Las Vegas, NA, 2003.

28 Jeff Wilson, Osamu Matsushita, Joshua Sakon, Ca2+ induced switch from helix to sheet triggers collagen binding. American Crystallographic Association Annual Meeting, July 21, 2001.

29 Leroux, Jean-Yves, Ph.D., a well-known Canadian immunologist specializing in collagen research, speaking during a nationally broadcast television special, The Loss of Youth, 2003.

30 Hunter, G.K. and Goldberg, H.A. (1994) Modulation of Crystal Formation by Bone Phosphoproteins: Role of Glutamic Acid-Rich Sequences in the Nucleation of Hydroxyapatite by Bone Sialoprotein. Biochemistry Journal, 302, 175-179.

31 N.A. Nandriopoulos et al., Arthritis Rheum. 19, 613 (1976); D.E. Trentham, R.A. Dynesisus, R.E. Rocklin, J.R. David, New England Journal of Medicine, 299, 327 (1978); A. Tarkowski, L. Klareskog, H. Carlsten, P. Herberts, W.J. Koopman, Arthritis Rheumatism, 32, 1087 (1989).

32 Leroux, Jean-Yves, Ph.D., a well-known Canadian immunologist specializing in collagen research, speaking during a nationally broadcast television special, The Loss of Youth, 2003.

33 Dr. Sal Martingano, March 2003.

34 Dr. Jean-Yves Leroux, Immunologist/Bio-Chemist, May 2003.

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